Cisco ISR4351-DNA Integrated Services Router

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ISR4351-DNA Overview

The Cisco

ISR4351-DNA is a powerful Integrated Services Router designed for medium-sized businesses seeking high-performance networking solutions. With robust security features, flexible networking options, and scalable performance, it is ideal for environments demanding reliable connectivity and advanced data handling capabilities.

Cisco 

ISR4351-DNA Product Highlights

  • ● 3 GE Ports
  • ● 3 NIM Slots
  • ● 2 SM Slots
  • ● 4G Flash Memory
  • ● 4G DRAM
  • ● Integrated DNA

Product Features Comparison

Features Cisco 

ISR4351-DNA

Cisco ISR4331 Juniper SRX340 HP MSR1003 Adtran NetVanta 3140 Huawei AR3200 Fortinet FG-80F
Network Interfaces 3 GE 2 GE 4 GE 3 GE 2 GE 4 GE 3 GE
NIM Slots 3 2 3 3 2 3 2
SM Slots 2 1 2 2 1 2 1
Flash Memory 4G 4G 8G 4G 8G 4G 8G
DRAM 4G 4G 2G 4G 2G 4G 4G
DNA Integration Yes No No No No No No

Cisco 

ISR4351-DNA Product Application Scenarios

  • ● Medium-sized office networks
  • ● Secure branch connectivity
  • ● Advanced data processing

Optional Add-ons

Model Description
MEM-4350-4GB 4GB DRAM Upgrade
FL-ISR-DNA DNA Software License

NIM-ES2-8

8-Port GE Network Module
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ISR4351-DNA Specifications

Model Number ISR4351-DNA
Brand Cisco
Ethernet Ports 3 GE
Network Interface Modules (NIM) 3 NIM slots
Service Module Slots (SM) 2 SM slots
Flash Memory 4 GB
DRAM 4 GB
License DNA
Type Router
Dimensions 44.5 mm x 369.6 mm x 438.2 mm
Interface Cards Yes
Redundant Power Supply Yes
USB Ports 2 USB 2.0 ports
Serial Interfaces Yes
Console Ports 1 serial console port, 1 USB console port
Management Port 1 GE management port
Operating Temperature 0 to 40°C
Storage Temperature -20 to 65°C
Power Supply AC 100-240V, 60-50Hz
Max Power Consumption 250W

Frequently Asked Questions

The ISR4351-DNA is a Cisco 4000 Series Integrated Services Router bundle that includes the ISR4351 hardware with Cisco DNA software licensing, enabling advanced SD-WAN, automation, and software-defined networking features for enterprise branch deployments. It is designed for secure WAN connectivity and centralized network controll
The “DNA” in ISR4351-DNA refers to Cisco Digital Network Architecture (DNA) licensing. This software layer unlocks features such as SD-WAN, automation, analytics, and centralized policy management that go beyond traditional routing capabilities.
Yes. The main difference is licensing: ISR4351-DNA → Includes Cisco DNA software entitlement ISR4351-AX → AppX licensing for advanced applications ISR4351/K9 → Base hardware without advanced DNA package Many enterprise buyers choose DNA versions for SD-WAN and automation use cases
Yes. ISR4351 models can run Cisco IOS XE SD-WAN, allowing centralized control, application-aware routing, and secure branch connectivity across distributed enterprise locations.
The ISR4351-DNA is commonly used for: Enterprise branch routing SD-WAN deployments Secure VPN connectivity WAN edge routing
Yes — but it is in lifecycle transition. The Cisco 4351 ISR platform has an End-of-Sale date of 7 Nov 2023, while support continues until 30 Nov 2028. This is important for enterprises planning lifecycle upgrades.
Yes. It is widely deployed in enterprise branch environments because it combines: Enterprise-grade routing Software-defined WAN capabilities Secure connectivity Reliable branch performance It is often used as a core branch WAN edge router.
Key advantages include: Access to Cisco DNA automation features SD-WAN capability and centralized control Improved application visibility Easier network scalability This makes ISR4351-DNA better aligned with modern software-defined networking strategies.
Yes. With Cisco DNA licensing and SD-WAN functionality, ISR4351-DNA enables secure connectivity between branches, data centers, and cloud services, making it suitable for hybrid IT environments.

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